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| Product Name: |
Damnacanthal CAS NO 477-84-9
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| Supply Ability: |
500 |
| Related proudcts |
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| Specifications |
98% purity |
| Price Term: |
FOB , CNF, CIF . EXW |
| Port of loading: |
Shenzhen |
| Minimum Order |
1G |
| Unit Price: |
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Damnacanthal
***ailed Information:
Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde CAS NO 477-84-9
Synonym Damnacanthal Molecular Weight 282.34
M.F: C16H10O5 Purity 98%min
Appearance Orange-yellow solid Place of origin China
Solubility Soluble to 25 mM in DMSO Certificate SGS
***uments available COA,MSDS,NMR, HPLC Packing 1Kg/bag
25Kg/Drum
Shelf life 2 years Storage -20 °C, sealed, avoid light,in N2
Description:
Damnacanthal is an anthraquinone which acts as a p56lck tyrosine kinase inhibitor. It can be extracted from Morinda citrifolia. have long been used in traditional medicine for the treatment of cancer .
Name 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
Synonym Damnacanthal
Assay �98%min
CAS 477-84-9
Molecular formula: C16H10O5
Percentage Composition: C 68.09%; H 3.57%; O 28.34%
Melting Point: Mp 218-218.5â„?
Physical Description: Orange-yellow solid
Biological Source extracted from Morinda citrifolia.
primary target p56lck autophosphorylation
primary target IC50 17 nM against p56lck autophosphorylation
Packaging: Packaged under inert gas
Storage -20 °C, sealed, avoid light,in N2
Usage A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase
The period of validity 2 years
Overview
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase acti |
| Company: |
Shenzhen Dieckmann Technology Co.,Ltd
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| Contact: |
Mr. nancy feng |
| Address: |
2floor,3 building, Maluan Make Place,2-10south of Jinlong Road, Pingshan New district,Shenzhen |
| Postcode: |
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| Tel: |
89213952 |
| Fax: |
84813563 |
| E-mail: |
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